Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange
نویسندگان
چکیده
منابع مشابه
Effect of parental morphine addiction on extracellular glutamate concentration of dentate gyrus in rat offsprings
Introduction: Evidences show that parental morphine addiction impairs CNS development, learning and memory in offsprings. Regarding the role of glutamate in dentate gyrus on learning and memory, in this study the effect of parental morphine addiction on extracellular glutamate concentration of dentate gyrus was assessed. Materials and methods: In this study 20 female and 8 male rats were addic...
متن کاملThe effect of parental morphine addiction on extracellular glutamate concentration of dentate gyrus in rat offspring: a microdialysis study
Addiction is a major problem of society. The existing evidences have shown that parental addiction impairs CNS development, learning, and memory. With respect to the role of glutamate in dentate gyrus on learning and memory, in this study, the effect of parental addiction to morphine on extracellular glutamate concentration in dentate gyrus was evaluated. For this purpose, male and female rats ...
متن کاملThe effect of parental morphine addiction on extracellular glutamate concentration of dentate gyrus in rat offspring: a microdialysis study
Addiction is a major problem of society. The existing evidences have shown that parental addiction impairs CNS development, learning, and memory. With respect to the role of glutamate in dentate gyrus on learning and memory, in this study, the effect of parental addiction to morphine on extracellular glutamate concentration in dentate gyrus was evaluated. For this purpose, male and female rats ...
متن کاملModulation of Glutamate Transport and Receptor Binding by Glutamate Receptor Antagonists in EAE Rat Brain
The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The elevation of glutamate in cerebrospinal fluid, as well as changes in the expression of glutamate receptors (iGluRs and mGluRs) and excitatory amino acid transporters (EAATs), have been observed in the brains of MS patients and animals subjected to exp...
متن کاملExtracellular glutamate concentration in hippocampal slice.
Synaptic glutamate transients resulting from vesicular exocytosis are superimposed on a low baseline concentration of glutamate in the extracellular space. Reported values of baseline glutamate concentrations range up to 4 microM. If glutamate were present tonically at low micromolar concentrations, many receptors, especially the high-affinity NMDA receptors (NMDARs), would be activated or dese...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1999
ISSN: 0022-3751
DOI: 10.1111/j.1469-7793.1999.783ad.x